Trung tâm Thông tin - Thư viện Trường Đại học Y Dược Hải Phòng

NLM	B13
Tác giả CN	Nguyễn Thị Thu Phương - Cb.
Nhan đề	Impact of Ginkgo biloba drug interactions on bleeding risk and coagulation profiles: A comprehensive analysis
Thông tin xuất bản	Public Library of Science,2025
Tóm tắt	Our analysis utilized data from patients admitted to Hai Phong International Hospital between January 2022 and December 2023. Inclusion criteria consisted of patients aged 18 years and above, those prescribed Ginkgo biloba extract alone or in combination with other medications, and the availability of complete medical records, including medication history, laboratory tests, and clinical outcomes. Out of 2,647 prescriptions meeting the inclusion criteria, 342 exhibited drug interactions with a prevalence rate of 12.94%. Notably, Ginkgo biloba extract frequent interacts with antiplatelets, anticoagulants, and nonsteroidal anti-inflammatory drugs, with Clopidogrel and Aspirin exhibiting the highest prevalence rates of 2.61% each. However, interactions with anticoagulants including direct oral anticoagulants and acenocoumarol, were not statistically significant in our analysis. Omeprazole was a frequently interacting drug (2.34%) of mild severity. Among the 747 patients analyzed for bleeding disorders, 31 (4.15%) exhibited bleeding symptoms. Correlation analysis indicated a strong association between clinical bleeding and abnormal coagulation results (OR, 1.75; p < 0.001). Moreover, significant correlations were found between Ginkgo biloba extract drug interactions and the bleeding risk (OR: 1.08, p < 0.001) and abnormal coagulation (OR: 1.49, p < 0.001). The severity of Ginkgo biloba extract drug interactions did not correlate with bleeding risk (OR: 1.01, p = 0.767) but influenced abnormal coagulation test results (OR: 0.813, p = 0.019). Specific medications, including clopidogrel, aspirin, celecoxib, loxoprofen, nifedipine, and omeprazole, were significantly associated with the risk of bleeding and abnormal coagulation (p < 0.05).
Thuật ngữ chủ đề	Multidisciplinary; Pharmacy
Từ khóa tự do	Ginkgo biloba
Tác giả(bs) CN	Ngô Thị Quỳnh Mai
Tác giả(bs) CN	Trần Thị Ngân
Địa chỉ	100Bài báo quốc tế(1): BQT00003
Tệp tin điện tử	https://pubmed.ncbi.nlm.nih.gov/40198642/
Tệp tin điện tử	https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg

MARC

Hiển thị đầy đủ trường & trường con

Tag	Giá trị
000	00000nab#a2200000u##4500
001	33900
002	13
004	09E25EBC-875A-4FE1-B711-DDDC85D73F36
005	202605111528
008	260507s2025 xx eng
009	1 0
039	[ ] \|a 20260511152804 \|b phuongntt \|y 20260506190648 \|z phuongntt
041	[ ] \|a Eng
084	[ ] \|a B13
100	[ ] \|a Nguyễn Thị Thu Phương \|e Cb.
245	[ ] \|a Impact of Ginkgo biloba drug interactions on bleeding risk and coagulation profiles: A comprehensive analysis
260	[ ] \|b Public Library of Science, \|c 2025
520	[ ] \|a Our analysis utilized data from patients admitted to Hai Phong International Hospital between January 2022 and December 2023. Inclusion criteria consisted of patients aged 18 years and above, those prescribed Ginkgo biloba extract alone or in combination with other medications, and the availability of complete medical records, including medication history, laboratory tests, and clinical outcomes. Out of 2,647 prescriptions meeting the inclusion criteria, 342 exhibited drug interactions with a prevalence rate of 12.94%. Notably, Ginkgo biloba extract frequent interacts with antiplatelets, anticoagulants, and nonsteroidal anti-inflammatory drugs, with Clopidogrel and Aspirin exhibiting the highest prevalence rates of 2.61% each. However, interactions with anticoagulants including direct oral anticoagulants and acenocoumarol, were not statistically significant in our analysis. Omeprazole was a frequently interacting drug (2.34%) of mild severity. Among the 747 patients analyzed for bleeding disorders, 31 (4.15%) exhibited bleeding symptoms. Correlation analysis indicated a strong association between clinical bleeding and abnormal coagulation results (OR, 1.75; p < 0.001). Moreover, significant correlations were found between Ginkgo biloba extract drug interactions and the bleeding risk (OR: 1.08, p < 0.001) and abnormal coagulation (OR: 1.49, p < 0.001). The severity of Ginkgo biloba extract drug interactions did not correlate with bleeding risk (OR: 1.01, p = 0.767) but influenced abnormal coagulation test results (OR: 0.813, p = 0.019). Specific medications, including clopidogrel, aspirin, celecoxib, loxoprofen, nifedipine, and omeprazole, were significantly associated with the risk of bleeding and abnormal coagulation (p < 0.05).
650	[ ] \|a Multidisciplinary
650	[ ] \|a Pharmacy
653	[ ] \|a Ginkgo biloba
700	[ ] \|a Ngô Thị Quỳnh Mai
700	[ ] \|a Trần Thị Ngân
773	[ ] \|t PLoS One
852	[ ] \|a 100 \|b Bài báo quốc tế \|j (1): BQT00003
856	[ ] \|u https://pubmed.ncbi.nlm.nih.gov/40198642/
856	[1 ] \|u https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
890	[ ] \|a 1 \|b 0 \|c 0 \|d 0

Dòng	Mã vạch	Bản sao	Nơi lưu	Tình trạng	Cho phép yêu cầu
1	BQT00003	1	Kho Bài báo quốc tế
#1 BQT00003 Nơi lưu Kho Bài báo quốc tế Tình trạng

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