Trung tâm Thông tin - Thư viện Trường Đại học Y Dược Hải Phòng

NLM	B13
Tác giả CN	Bùi Thị Thắm
Nhan đề	Model-Based Meta-Analysis of the Relationship Between Pioglitazone and Histological Outcomes in Metabolic Dysfunction-Associated Steatohepatitis Patients
Thông tin xuất bản	Wiley,2025
Tóm tắt	Our study aimed to perform a model-based meta-analysis to quantitatively examine the efficacy of pioglitazone in improving histological parameters and liver enzymes in patients with MASH. A comprehensive search was performed in Pubmed and clinicaltrials.gov. We collected histological outcomes (including steatosis, inflammation, ballooning, and fibrosis) and liver enzyme data. Due to sparse data, the gathered histological outcomes were used to generate virtual data. Next, model development for the virtual histological dataset was performed using a logistic model. In addition, Weibull and exponential models were tested to find the best fit for liver enzyme data. Model evaluations were carried out by visual predictive check, bootstrap method, and stacked bar plot. Eight studies with 540 patients were included. A logit model was used to analyze four outcomes. The results showed that using pioglitazone improved all four histological parameters. These effects are dose- and time-dependent under the Emax-time model for steatosis and ballooning, and under the linear relationship for inflammation and fibrosis. For liver enzymes, the Weibull model fitted well for both ALT and AST data. In conclusion, the developed models of pioglitazone may serve as a benchmark to assess the effectiveness of novel MASH-targeted treatments.
Thuật ngữ chủ đề	Pharmacometrics; Pharmacology
Từ khóa tự do	MASH; MBMA
Địa chỉ	100Bài báo quốc tế(1): BQT00005
Tệp tin điện tử	https://pubmed.ncbi.nlm.nih.gov/40248984/
Tệp tin điện tử	https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg

MARC

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Tag	Giá trị
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001	33902
002	13
004	52491745-21F5-413E-A6EB-35B47F4E2C53
005	202605111527
008	081223s2025 vm\| vie
009	1 0
039	[ ] \|a 20260511152721 \|b phuongntt \|c 20260506193200 \|d phuongntt \|y 20260506192341 \|z phuongntt
041	[ ] \|a Eng
084	[ ] \|a B13
100	[ ] \|a Bùi Thị Thắm
245	[ ] \|a Model-Based Meta-Analysis of the Relationship Between Pioglitazone and Histological Outcomes in Metabolic Dysfunction-Associated Steatohepatitis Patients
260	[ ] \|b Wiley, \|c 2025
520	[ ] \|a Our study aimed to perform a model-based meta-analysis to quantitatively examine the efficacy of pioglitazone in improving histological parameters and liver enzymes in patients with MASH. A comprehensive search was performed in Pubmed and clinicaltrials.gov. We collected histological outcomes (including steatosis, inflammation, ballooning, and fibrosis) and liver enzyme data. Due to sparse data, the gathered histological outcomes were used to generate virtual data. Next, model development for the virtual histological dataset was performed using a logistic model. In addition, Weibull and exponential models were tested to find the best fit for liver enzyme data. Model evaluations were carried out by visual predictive check, bootstrap method, and stacked bar plot. Eight studies with 540 patients were included. A logit model was used to analyze four outcomes. The results showed that using pioglitazone improved all four histological parameters. These effects are dose- and time-dependent under the Emax-time model for steatosis and ballooning, and under the linear relationship for inflammation and fibrosis. For liver enzymes, the Weibull model fitted well for both ALT and AST data. In conclusion, the developed models of pioglitazone may serve as a benchmark to assess the effectiveness of novel MASH-targeted treatments.
650	[ ] \|a Pharmacometrics
650	[ ] \|a Pharmacology
653	[ ] \|a MASH
653	[ ] \|a MBMA
773	[ ] \|t CPT: Pharmacometrics & Systems Pharmacology
852	[ ] \|a 100 \|b Bài báo quốc tế \|j (1): BQT00005
856	[ ] \|u https://pubmed.ncbi.nlm.nih.gov/40248984/
856	[1 ] \|u https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
890	[ ] \|a 1 \|b 0 \|c 0 \|d 0

Dòng	Mã vạch	Bản sao	Nơi lưu	Tình trạng	Cho phép yêu cầu
1	BQT00005	1	Kho Bài báo quốc tế
#1 BQT00005 Nơi lưu Kho Bài báo quốc tế Tình trạng

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