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A umbilical cord blood-derived exosome product simulates hair growth through laminin V and collagen XVII an ex vivo study

A umbilical cord blood-derived exosome product simulates hair growth through laminin V and collagen XVII an ex vivo study

 Lê Thị Thùy Linh
 Springer 2025
 Eng
Medical technologyLaminin V and collagen XVIIExosome product
Mô tả biểu ghi
ID:33959
NLM B16
Tác giả CN Lê Thị Thùy Linh
Nhan đề A umbilical cord blood-derived exosome product simulates hair growth through laminin V and collagen XVII: an ex vivo study
Thông tin xuất bản 2025
Thông tin xuất bản Springer
Tóm tắt This study was to investigate the safety and efficacy of Limelight (CB-EVs) for hair growth ex vivo. Our analysis revealed that concentrations of Limelight (CB-EVs) below 5 U/ml demonstrated no cytotoxicity in vitro through MTS assay. In hair follicle culture, concentrations of 0.1, 0.01, and 0.001 U/ml significantly promoted hair elongation while maintaining hair bulb diameter. Analysis of the hair growth cycle indicated a reduced transition from the anagen phase to the catagen phase. Overexpression of Laminin V and Collagen XVII were seen by immunohistochemistry staining. These results endorse the exosome product, Limelight (CB-EVs), offers a safe and effective method for stimulating hair growth ex vivo.
Thuật ngữ chủ đề Medical technology
Từ khóa tự do Laminin V and collagen XVII; Exosome product
Địa chỉ 100Kho Bài báo quốc tế(1): BQT00045
Tệp tin điện tử https://link.springer.com/article/10.1007/s00403-025-04392-8
Tệp tin điện tử https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
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041[ ] |a Eng
084[ ] |a B16
100[ ] |a Lê Thị Thùy Linh
245[ ] |a A umbilical cord blood-derived exosome product simulates hair growth through laminin V and collagen XVII: an ex vivo study
260[ ] |c 2025
260[ ] |b Springer
520[ ] |a This study was to investigate the safety and efficacy of Limelight (CB-EVs) for hair growth ex vivo. Our analysis revealed that concentrations of Limelight (CB-EVs) below 5 U/ml demonstrated no cytotoxicity in vitro through MTS assay. In hair follicle culture, concentrations of 0.1, 0.01, and 0.001 U/ml significantly promoted hair elongation while maintaining hair bulb diameter. Analysis of the hair growth cycle indicated a reduced transition from the anagen phase to the catagen phase. Overexpression of Laminin V and Collagen XVII were seen by immunohistochemistry staining. These results endorse the exosome product, Limelight (CB-EVs), offers a safe and effective method for stimulating hair growth ex vivo.
650[ ] |a Medical technology
653[ ] |a Laminin V and collagen XVII
653[ ] |a Exosome product
773[ ] |t Archives of Dermatological Research
852[ ] |a 100 |b Kho Bài báo quốc tế |j (1): BQT00045
856[ ] |u https://link.springer.com/article/10.1007/s00403-025-04392-8
856[1 ] |u https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
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1 BQT00045 1 Kho Bài báo quốc tế
#1 BQT00045
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