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Spermidine Reproduces the Anti-Inflammatory Effects of Intermittent Fasting and Prevents Urate and Calcium Pyrophosphate Crystal-Induced Inflammation

Spermidine Reproduces the Anti-Inflammatory Effects of Intermittent Fasting and Prevents Urate and Calcium Pyrophosphate Crystal-Induced Inflammation

 Phạm Chính Nghĩa
 WILEY 2025
 Eng
Internal medicineMonosodium urate (MSU)Calcium pyrophosphate (CPP)
Mô tả biểu ghi
ID:33979
NLM C5
Tác giả CN Phạm Chính Nghĩa
Nhan đề Spermidine Reproduces the Anti-Inflammatory Effects of Intermittent Fasting and Prevents Urate and Calcium Pyrophosphate Crystal-Induced Inflammation
Thông tin xuất bản 2025
Thông tin xuất bản WILEY
Tóm tắt We observe that two nonconsecutive days of fasting during one week significantly prevents the inflammation provoked by MSU and CPP crystal injection into the air pouch cavity in a mouse model. This short-term fasting is associated with increased serum abundances of numerous anti-inflammatory metabolites, including β-hydroxybutyrate and spermidine (SPD), a polyamine able to reproduce biologic effects of IF. Conversely, crystal stimulation in mice fed ad libitum decreases the local production of these metabolites in the air pouch membrane. Supplementation of SPD reproduces the anti-inflammatory effect of IF and prevents crystal-induced inflammation through inhibition of NF-κB and NLRP3 inflammasome. Finally, down-regulation of SPD/spermine acetyltransferase 1, which encodes the enzyme that degrades SPD, reduces IL-1β production induced by crystal stimulation.
Thuật ngữ chủ đề Internal medicine
Từ khóa tự do Monosodium urate (MSU); Calcium pyrophosphate (CPP)
Địa chỉ 100Kho Bài báo quốc tế(1): BQT00061
Tệp tin điện tử https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.43367
Tệp tin điện tử https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
MARC
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041[ ] |a Eng
084[ ] |a C5
100[ ] |a Phạm Chính Nghĩa
245[ ] |a Spermidine Reproduces the Anti-Inflammatory Effects of Intermittent Fasting and Prevents Urate and Calcium Pyrophosphate Crystal-Induced Inflammation
260[ ] |c 2025
260[ ] |b WILEY
520[ ] |a We observe that two nonconsecutive days of fasting during one week significantly prevents the inflammation provoked by MSU and CPP crystal injection into the air pouch cavity in a mouse model. This short-term fasting is associated with increased serum abundances of numerous anti-inflammatory metabolites, including β-hydroxybutyrate and spermidine (SPD), a polyamine able to reproduce biologic effects of IF. Conversely, crystal stimulation in mice fed ad libitum decreases the local production of these metabolites in the air pouch membrane. Supplementation of SPD reproduces the anti-inflammatory effect of IF and prevents crystal-induced inflammation through inhibition of NF-κB and NLRP3 inflammasome. Finally, down-regulation of SPD/spermine acetyltransferase 1, which encodes the enzyme that degrades SPD, reduces IL-1β production induced by crystal stimulation.
650[ ] |a Internal medicine
653[ ] |a Monosodium urate (MSU)
653[ ] |a Calcium pyrophosphate (CPP)
773[ ] |t Arthritis&Rheumatology
852[ ] |a 100 |b Kho Bài báo quốc tế |j (1): BQT00061
856[ ] |u https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.43367
856[1 ] |u https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
890[ ] |a 1 |b 0 |c 0 |d 0
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1 BQT00061 1 Kho Bài báo quốc tế
#1 BQT00061
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