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NLM	C24
Tác giả CN	Đặng Tuấn Anh
Nhan đề	BMP-2 generates a functional bone marrow niche by inducing the differentiation of local mesenchymal cells into CAR cells
Thông tin xuất bản	2025
Thông tin xuất bản	ASH Publications
Tóm tắt	In this study, through the use of single-cell RNA sequencing and transplantation models, we demonstrate that BMP-eBM displays a microstructure, cellular composition, and functional hematopoiesis similar to LB-BM. BMP-eBM establishes an optimized microenvironment capable of supporting hematopoietic stem cells and CXC chemokine ligand 12 (CXCL12)–abundant reticular (CAR) cells, which are critical components of the BM niche. BMP-eBM was able to significantly restore survival in irradiated mice. Through parabiosis and cell transplantation experiments, we identified that in situ adipose tissue–derived CD51highCxcl12-GFP– cells are the principal source of CAR cells within BMP-eBM. Furthermore, BMP-eBM can be isolated and after preconditioning, retransplanted as an independent, functional hematopoietic organ.
Thuật ngữ chủ đề	Odontology
Từ khóa tự do	Hematopoiesis and Stem Cells; Transplantation
Địa chỉ	100Kho Bài báo quốc tế(1): BQT00063
Tệp tin điện tử	https://doi.org/10.1182/bloodadvances.2024014062
Tệp tin điện tử	https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg

MARC

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Tag	Giá trị
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001	33982
002	13
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005	202605141549
008	081223s2025 vm\| vie
009	1 0
039	[ ] \|y 20260514154948 \|z phuongntt
041	[ ] \|a Eng
084	[ ] \|a C24
100	[ ] \|a Đặng Tuấn Anh
245	[ ] \|a BMP-2 generates a functional bone marrow niche by inducing the differentiation of local mesenchymal cells into CAR cells
260	[ ] \|c 2025
260	[ ] \|b ASH Publications
520	[ ] \|a In this study, through the use of single-cell RNA sequencing and transplantation models, we demonstrate that BMP-eBM displays a microstructure, cellular composition, and functional hematopoiesis similar to LB-BM. BMP-eBM establishes an optimized microenvironment capable of supporting hematopoietic stem cells and CXC chemokine ligand 12 (CXCL12)–abundant reticular (CAR) cells, which are critical components of the BM niche. BMP-eBM was able to significantly restore survival in irradiated mice. Through parabiosis and cell transplantation experiments, we identified that in situ adipose tissue–derived CD51highCxcl12-GFP– cells are the principal source of CAR cells within BMP-eBM. Furthermore, BMP-eBM can be isolated and after preconditioning, retransplanted as an independent, functional hematopoietic organ.
650	[ ] \|a Odontology
653	[ ] \|a Hematopoiesis and Stem Cells
653	[ ] \|a Transplantation
773	[ ] \|t Blood Advance
852	[ ] \|a 100 \|b Kho Bài báo quốc tế \|j (1): BQT00063
856	[ ] \|u https://doi.org/10.1182/bloodadvances.2024014062
856	[1 ] \|u https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
890	[ ] \|a 1 \|b 0 \|c 0 \|d 0

Dòng	Mã vạch	Bản sao	Nơi lưu	Tình trạng	Cho phép yêu cầu
1	BQT00063	1	Kho Bài báo quốc tế
#1 BQT00063 Nơi lưu Kho Bài báo quốc tế Tình trạng

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