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Leucine-rich Repeat-containing 15 as a Potential Marker and Therapeutic Target in Cervical Cancer

Leucine-rich Repeat-containing 15 as a Potential Marker and Therapeutic Target in Cervical Cancer

 INT INST ANTICANCER RESEARCH, 2025
 Eng
Mô tả biểu ghi
ID:33997
NLM C20
Tác giả CN Đào Thị Hải Ly - Cb.
Nhan đề Leucine-rich Repeat-containing 15 as a Potential Marker and Therapeutic Target in Cervical Cancer
Thông tin xuất bản INT INST ANTICANCER RESEARCH,2025
Tóm tắt LRRC15 expression was significantly associated with lympho-vascular space (LVS) involvement in patients with CC (p<0.001). Patients with high LRRC15 expression had significantly poorer progression-free survival outcomes than those with low LRRC15 expression (p=0.014). LRRC15 knockdown suppressed WNT and focal adhesion kinase (FAK) signaling, leading to increased Caspase3/7 expression and, consequently, enhanced apoptosis in CC cells, regardless of HPV infection.
Thuật ngữ chủ đề Obstetrics
Từ khóa tự do Cancer-associated fibroblasts; Cervical cancer
Tác giả(bs) CN Vũ Thúy Hà
Địa chỉ 100Kho Bài báo quốc tế(1): BQT00074
Tệp tin điện tử https://pubmed.ncbi.nlm.nih.gov/41318123/
Tệp tin điện tử https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
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TagGiá trị
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041[ ] |a Eng
084[ ] |a C20
100[ ] |a Đào Thị Hải Ly |e Cb.
245[ ] |a Leucine-rich Repeat-containing 15 as a Potential Marker and Therapeutic Target in Cervical Cancer
260[ ] |b INT INST ANTICANCER RESEARCH, |c 2025
520[ ] |a LRRC15 expression was significantly associated with lympho-vascular space (LVS) involvement in patients with CC (p<0.001). Patients with high LRRC15 expression had significantly poorer progression-free survival outcomes than those with low LRRC15 expression (p=0.014). LRRC15 knockdown suppressed WNT and focal adhesion kinase (FAK) signaling, leading to increased Caspase3/7 expression and, consequently, enhanced apoptosis in CC cells, regardless of HPV infection.
650[ ] |a Obstetrics
653[ ] |a Cancer-associated fibroblasts
653[ ] |a Cervical cancer
691[ ] |a CTĐT Bác sĩ nội trú Sản phụ khoa
700[ ] |a Vũ Thúy Hà
773[ ] |t Anticancer Research
852[ ] |a 100 |b Kho Bài báo quốc tế |j (1): BQT00074
856[ ] |u https://pubmed.ncbi.nlm.nih.gov/41318123/
856[1 ] |u https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
890[ ] |a 1 |b 0 |c 0 |d 0
Dòng Mã vạch Bản sao Nơi lưu Tình trạng Cho phép yêu cầu
1 BQT00074 1 Kho Bài báo quốc tế
#1 BQT00074
Nơi lưu Kho Bài báo quốc tế
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