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Evaluating the Diagnostic Utility of 16S Oxford Nanopore Technology Sequencing in Patients With Central Nervous System Infections and Its Usefulness in Antimicrobial Stewardship

Evaluating the Diagnostic Utility of 16S Oxford Nanopore Technology Sequencing in Patients With Central Nervous System Infections and Its Usefulness in Antimicrobial Stewardship

 Trần Thị Liên
 2025
 Eng
InfectiousCentral nervous systemCerebrospinal fluid
Mô tả biểu ghi
ID:34016
NLM C7
Tác giả CN Trần Thị Liên
Nhan đề Evaluating the Diagnostic Utility of 16S Oxford Nanopore Technology Sequencing in Patients With Central Nervous System Infections and Its Usefulness in Antimicrobial Stewardship
Thông tin xuất bản 2025
Tóm tắt Of the 329 samples, 40 (12%) were positive for bacterial or fungal pathogens. 16S ONT detected pathogens in 28 samples (9%), while CSF culture identified pathogens in 23 samples (7%). 16S ONT sequencing identified 17 pathogens not detected by CSF culture, including Streptococcus suis and Acinetobacter baumannii. Based on 16S ONT findings, 61% of patients were found to have received inappropriate empirical antibiotic therapy and could have benefited from improved antimicrobial management, including de-escalation in 11, escalation in 5, and adjustments in 2 cases.
Thuật ngữ chủ đề Infectious
Từ khóa tự do Central nervous system; Cerebrospinal fluid
Địa chỉ 100Kho Bài báo quốc tế(1): BQT00093
Tệp tin điện tử https://doi.org/10.1093/infdis/jiaf280
Tệp tin điện tử https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
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041[ ] |a Eng
084[ ] |a C7
100[ ] |a Trần Thị Liên
245[ ] |a Evaluating the Diagnostic Utility of 16S Oxford Nanopore Technology Sequencing in Patients With Central Nervous System Infections and Its Usefulness in Antimicrobial Stewardship
260[ ] |c 2025
520[ ] |a Of the 329 samples, 40 (12%) were positive for bacterial or fungal pathogens. 16S ONT detected pathogens in 28 samples (9%), while CSF culture identified pathogens in 23 samples (7%). 16S ONT sequencing identified 17 pathogens not detected by CSF culture, including Streptococcus suis and Acinetobacter baumannii. Based on 16S ONT findings, 61% of patients were found to have received inappropriate empirical antibiotic therapy and could have benefited from improved antimicrobial management, including de-escalation in 11, escalation in 5, and adjustments in 2 cases.
650[ ] |a Infectious
653[ ] |a Central nervous system
653[ ] |a Cerebrospinal fluid
691[ ] |a CTĐT Bác sĩ nội trú Nội khoa
691[ ] |a CTĐT Y khoa - Chính quy
773[ ] |t National Library of Medicine
852[ ] |a 100 |b Kho Bài báo quốc tế |j (1): BQT00093
856[ ] |u https://doi.org/10.1093/infdis/jiaf280
856[1 ] |u https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
890[ ] |a 1 |b 0 |c 0 |d 0
Dòng Mã vạch Bản sao Nơi lưu Tình trạng Cho phép yêu cầu
1 BQT00093 1 Kho Bài báo quốc tế
#1 BQT00093
Nơi lưu Kho Bài báo quốc tế
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