Trung tâm Thông tin - Thư viện Trường Đại học Y Dược Hải Phòng

NLM	B9
Tác giả CN	Bạch Thị Như Quỳnh
Nhan đề	Cloning and Functional Characterization of a Novel Brevinin-1-Type Peptide from Sylvirana guentheri with Anticancer Activity
Thông tin xuất bản	2025
Thông tin xuất bản	MDPI
Tóm tắt	The brevinin-1 E8.13 peptide was successfully cloned, sequenced, and chemically synthesized. Functional assays revealed that brevinin-1 E8.13 possesses strong antibacterial activity against Staphylococcus aureus and exerts significant antiproliferative effects on various human cancer cell lines, including A549 (lung), AGS (gastric), Jurkat (leukemia), HCT116 (colorectal), HL60 (leukemia), and HepG2 (liver). The peptide demonstrated moderate to potent cytotoxic activity, with IC50 values ranging from 7.5 to 14.8 μM, depending on the cell type. Notably, brevinin-1 E8.13 exhibited low cytotoxicity toward normal human dermal fibroblast (HDF) cells and even promoted cell proliferation at lower concentrations.
Thuật ngữ chủ đề	Molecular biology
Từ khóa tự do	CAFLUX HepG2 cells; Sylvirana guentheri
Địa chỉ	100Kho Bài báo quốc tế(1): BQT00116
Tệp tin điện tử	https://pubmed.ncbi.nlm.nih.gov/40864826/
Tệp tin điện tử	https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg

MARC

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Tag	Giá trị
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005	202605201007
008	081223s2025 vm\| vie
009	1 0
039	[ ] \|y 20260520100727 \|z phuongntt
041	[ ] \|a Eng
084	[ ] \|a B9
100	[ ] \|a Bạch Thị Như Quỳnh
245	[ ] \|a Cloning and Functional Characterization of a Novel Brevinin-1-Type Peptide from Sylvirana guentheri with Anticancer Activity
260	[ ] \|c 2025
260	[ ] \|b MDPI
520	[ ] \|a The brevinin-1 E8.13 peptide was successfully cloned, sequenced, and chemically synthesized. Functional assays revealed that brevinin-1 E8.13 possesses strong antibacterial activity against Staphylococcus aureus and exerts significant antiproliferative effects on various human cancer cell lines, including A549 (lung), AGS (gastric), Jurkat (leukemia), HCT116 (colorectal), HL60 (leukemia), and HepG2 (liver). The peptide demonstrated moderate to potent cytotoxic activity, with IC50 values ranging from 7.5 to 14.8 μM, depending on the cell type. Notably, brevinin-1 E8.13 exhibited low cytotoxicity toward normal human dermal fibroblast (HDF) cells and even promoted cell proliferation at lower concentrations.
650	[ ] \|a Molecular biology
653	[ ] \|a CAFLUX HepG2 cells
653	[ ] \|a Sylvirana guentheri
691	[ ] \|a CTĐT Cử nhân Kỹ thuật XN - Chính quy
691	[ ] \|a CTĐT Thạc sĩ Kỹ thuật xét nghiệm y học
773	[ ] \|t Current issues in molecular biology
852	[ ] \|a 100 \|b Kho Bài báo quốc tế \|j (1): BQT00116
856	[ ] \|u https://pubmed.ncbi.nlm.nih.gov/40864826/
856	[1 ] \|u https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
890	[ ] \|a 1 \|b 0 \|c 0 \|d 0

Dòng	Mã vạch	Bản sao	Nơi lưu	Tình trạng	Cho phép yêu cầu
1	BQT00116	1	Kho Bài báo quốc tế
#1 BQT00116 Nơi lưu Kho Bài báo quốc tế Tình trạng

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