Trung tâm Thông tin - Thư viện Trường Đại học Y Dược Hải Phòng

NLM	C22
Tác giả CN	Phan Hữu Phúc
Nhan đề	Risk stratification of childhood infection using host markers of immune and endothelial activation in Asia (Spot Sepsis): a multi-country, prospective, cohort study
Thông tin xuất bản	2025
Thông tin xuất bản	ELSEVIER
Tóm tắt	3423 participants were recruited between March 5, 2020, and Nov 4, 2022, 18 (0·5%) of whom were lost to follow-up. 133 (3·9%) of 3405 participants developed severe febrile illness (22 deaths, 111 received organ support; weighted prevalence 0·34% [95% CI 0·28-0·41]). sTREM1 showed the highest prognostic accuracy to identify patients who would progress to severe febrile illness (AUC 0·86 [95% CI 0·82-0·90]), outperforming WHO danger signs (0·75 [0·71-0·80]; p<0·0001), LqSOFA (0·74 [0·69-0·78]; p<0·0001), and SIRS (0·63 [0·58-0·68]; p<0·0001). Combining WHO danger signs with sTREM1 (0·88 [95% CI 0·85-0·91]) did not improve accuracy in identifying progression to severe febrile illness over sTREM1 alone (p=0·24). Sensitivity for identifying progression to severe febrile illness was greater for sTREM1 (0·80 [95% CI 0·73-0·85]) than for WHO danger signs (0·72 [0·66-0·79]; NNT=3000), whereas specificities were comparable (0·81 [0·78-0·83] for sTREM1 vs 0·79 [0·76-0·82] for WHO danger signs). Discrimination of immune and endothelial activation markers was best for children who progressed to meet the outcome more than 48 h after enrolment (sTREM1: AUC 0·94 [95% CI 0·89-0·98]).
Thuật ngữ chủ đề	Pediatric
Từ khóa tự do	Childhood infection; Spot Sepsis
Địa chỉ	100Kho Bài báo quốc tế(1): BQT00120
Tệp tin điện tử	https://pubmed.ncbi.nlm.nih.gov/40774784/
Tệp tin điện tử	https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg

MARC

Hiển thị đầy đủ trường & trường con

Tag	Giá trị
000	00000nab#a2200000ui#4500
001	34049
002	13
004	0F652D88-20D8-495F-B045-73087474DE8C
005	202605201103
008	081223s2025 vm\| vie
009	1 0
039	[ ] \|y 20260520110307 \|z phuongntt
041	[ ] \|a Eng
084	[ ] \|a C22
100	[ ] \|a Phan Hữu Phúc
245	[ ] \|a Risk stratification of childhood infection using host markers of immune and endothelial activation in Asia (Spot Sepsis): a multi-country, prospective, cohort study
260	[ ] \|c 2025
260	[ ] \|b ELSEVIER
520	[ ] \|a 3423 participants were recruited between March 5, 2020, and Nov 4, 2022, 18 (0·5%) of whom were lost to follow-up. 133 (3·9%) of 3405 participants developed severe febrile illness (22 deaths, 111 received organ support; weighted prevalence 0·34% [95% CI 0·28-0·41]). sTREM1 showed the highest prognostic accuracy to identify patients who would progress to severe febrile illness (AUC 0·86 [95% CI 0·82-0·90]), outperforming WHO danger signs (0·75 [0·71-0·80]; p<0·0001), LqSOFA (0·74 [0·69-0·78]; p<0·0001), and SIRS (0·63 [0·58-0·68]; p<0·0001). Combining WHO danger signs with sTREM1 (0·88 [95% CI 0·85-0·91]) did not improve accuracy in identifying progression to severe febrile illness over sTREM1 alone (p=0·24). Sensitivity for identifying progression to severe febrile illness was greater for sTREM1 (0·80 [95% CI 0·73-0·85]) than for WHO danger signs (0·72 [0·66-0·79]; NNT=3000), whereas specificities were comparable (0·81 [0·78-0·83] for sTREM1 vs 0·79 [0·76-0·82] for WHO danger signs). Discrimination of immune and endothelial activation markers was best for children who progressed to meet the outcome more than 48 h after enrolment (sTREM1: AUC 0·94 [95% CI 0·89-0·98]).
650	[ ] \|a Pediatric
653	[ ] \|a Childhood infection
653	[ ] \|a Spot Sepsis
691	[ ] \|a CTĐT Tiến sĩ Nhi khoa
691	[ ] \|a CTĐT Bác sĩ nội trú Nhi khoa
773	[ ] \|t Lancet Child Adolesc Health
852	[ ] \|a 100 \|b Kho Bài báo quốc tế \|j (1): BQT00120
856	[ ] \|u https://pubmed.ncbi.nlm.nih.gov/40774784/
856	[1 ] \|u https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
890	[ ] \|a 1 \|b 0 \|c 0 \|d 0

Dòng	Mã vạch	Bản sao	Nơi lưu	Tình trạng	Cho phép yêu cầu
1	BQT00120	1	Kho Bài báo quốc tế
#1 BQT00120 Nơi lưu Kho Bài báo quốc tế Tình trạng

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