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Model-Based Evaluation of HangAmDan-B1 and Afatinib Combination Therapy in HCC827 Xenograft Mice with Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

Model-Based Evaluation of HangAmDan-B1 and Afatinib Combination Therapy in HCC827 Xenograft Mice with Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

 MDPI, 2025
 Eng
Mô tả biểu ghi
ID:33903
NLM B13
Tác giả CN Bùi Thị Thắm
Nhan đề Model-Based Evaluation of HangAmDan-B1 and Afatinib Combination Therapy in HCC827 Xenograft Mice with Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
Thông tin xuất bản MDPI,2025
Tóm tắt The PK/PD model confirmed HAD-B1 enhances the potency of AFT by 1.45-fold. Model-based simulations predicted that combination treatment maintains a lower tumor size compared to AFT monotherapy.
Thuật ngữ chủ đề Pharmacometrics; Pharmacology
Từ khóa tự do Drug–drug interactions; Pharmacodynamic modeling
Địa chỉ 100Bài báo quốc tế(1): BQT00006
Tệp tin điện tử https://pubmed.ncbi.nlm.nih.gov/40430565/
Tệp tin điện tử https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
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100[ ] |a Bùi Thị Thắm
245[ ] |a Model-Based Evaluation of HangAmDan-B1 and Afatinib Combination Therapy in HCC827 Xenograft Mice with Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
260[ ] |b MDPI, |c 2025
520[ ] |a The PK/PD model confirmed HAD-B1 enhances the potency of AFT by 1.45-fold. Model-based simulations predicted that combination treatment maintains a lower tumor size compared to AFT monotherapy.
650[ ] |a Pharmacometrics
650[ ] |a Pharmacology
653[ ] |a Drug–drug interactions
653[ ] |a Pharmacodynamic modeling
773[ ] |t Pharmaceuticals
852[ ] |a 100 |b Bài báo quốc tế |j (1): BQT00006
856[ ] |u https://pubmed.ncbi.nlm.nih.gov/40430565/
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1 BQT00006 1 Kho Bài báo quốc tế
#1 BQT00006
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