Trung tâm Thông tin - Thư viện Trường Đại học Y Dược Hải Phòng

NLM	B2
Tác giả CN	Phạm Thúy An
Nhan đề	Novel fusion protein REA induces robust prime protection against tuberculosis in mice
Thông tin xuất bản	2025
Thông tin xuất bản	Nature
Tóm tắt	In this study, we engineered a potent chimeric protein vaccine candidate, Rv2299cD2D3-ESAT-6-Ag85B (REA), which induced Th1 and Th17 responses via dendritic cell maturation. REA-activated macrophages operated the killing mechanisms of Mycobacterium tuberculosis (MTB), such as phagosomal maturation and phagolysosome fusion, through the (PI3K)–p38 MAPK-Ca2+-NADPH oxidase pathway. Dendritic cells and macrophages activated by REA elicited synergistic anti-mycobacterial responses. Notably, REA-immunized mice suppressed MTB growth to undetectable levels at 16 weeks post-infection, which was supported by gross and pathologic findings and acid-fast staining of the lung tissues, and maintained antigen-specific multifunctional IFN-γ+IL-2+TNF-α CD4+ T and long-lasting T cells producing cytokines in the tissues. Our findings suggest that REA is an outstanding prime prophylactic vaccine candidate against tuberculosis.
Thuật ngữ chủ đề	Public health
Từ khóa tự do	Novel fusion protein REA; Tuberculosis
Địa chỉ	100Kho Bài báo quốc tế(1): BQT00040
Tệp tin điện tử	https://www.nature.com/articles/s41541-025-01077-1
Tệp tin điện tử	https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg

MARC

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002	13
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008	081223s2025 vm\| vie
009	1 0
039	[ ] \|y 20260513093523 \|z phuongntt
041	[ ] \|a Eng
084	[ ] \|a B2
100	[ ] \|a Phạm Thúy An
245	[ ] \|a Novel fusion protein REA induces robust prime protection against tuberculosis in mice
260	[ ] \|c 2025
260	[ ] \|b Nature
520	[ ] \|a In this study, we engineered a potent chimeric protein vaccine candidate, Rv2299cD2D3-ESAT-6-Ag85B (REA), which induced Th1 and Th17 responses via dendritic cell maturation. REA-activated macrophages operated the killing mechanisms of Mycobacterium tuberculosis (MTB), such as phagosomal maturation and phagolysosome fusion, through the (PI3K)–p38 MAPK-Ca2+-NADPH oxidase pathway. Dendritic cells and macrophages activated by REA elicited synergistic anti-mycobacterial responses. Notably, REA-immunized mice suppressed MTB growth to undetectable levels at 16 weeks post-infection, which was supported by gross and pathologic findings and acid-fast staining of the lung tissues, and maintained antigen-specific multifunctional IFN-γ+IL-2+TNF-α CD4+ T and long-lasting T cells producing cytokines in the tissues. Our findings suggest that REA is an outstanding prime prophylactic vaccine candidate against tuberculosis.
650	[ ] \|a Public health
653	[ ] \|a Novel fusion protein REA
653	[ ] \|a Tuberculosis
773	[ ] \|t Npj Vaccines
852	[ ] \|a 100 \|b Kho Bài báo quốc tế \|j (1): BQT00040
856	[ ] \|u https://www.nature.com/articles/s41541-025-01077-1
856	[1 ] \|u https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
890	[ ] \|a 1 \|b 0 \|c 0 \|d 0

Dòng	Mã vạch	Bản sao	Nơi lưu	Tình trạng	Cho phép yêu cầu
1	BQT00040	1	Kho Bài báo quốc tế
#1 BQT00040 Nơi lưu Kho Bài báo quốc tế Tình trạng

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