Trung tâm Thông tin - Thư viện Trường Đại học Y Dược Hải Phòng

NLM	B2
Tác giả CN	Phạm Thúy An
Nhan đề	IFN-γ and IL-17 elicit synergistic anti-mycobacterial responses by inhibiting coronin-1A retention
Thông tin xuất bản	2025
Thông tin xuất bản	Nature
Tóm tắt	This study demonstrates that the downregulation of coronin-1A retention on the phagosome is a synergistic pathway for IFN-γ and IL-17 that kills Mycobacterium tuberculosis (Mtb) in macrophages. IL-17 alone does not play a role in intracellular Mtb killing but potentiates the anti-mycobactericidal pathway of IFN-γ. Co-treatment of IFN-γ/IL-17 inhibited phosphorylation of STAT3, induced LRG47 expression, and reduced retention of coronin-1A on phagosome, thereby eliciting phagolysosomal fusion and bacterial killing, which was proved through response analysis of IFN-γ/IL-17 in Mtb-infected macrophages transfected with small interfering RNA of coro1a, lrg47, or stat1. Determination of adjunctive therapeutic effect of IFN-γ, IL-17, or both with anti-mycobacterial drugs showed that the bacterial load in the tissue of mice co-treated with IFN-γ/IL-17, even at 1 ng/mL concentration each, was more rapidly reduced compared to those of IFN-γ injection or chemotherapy alone. It inhibited the re-growth after treatment termination
Thuật ngữ chủ đề	Public health
Từ khóa tự do	Anti-mycobacterial; Inhibiting coronin-1A retention
Địa chỉ	100Kho Bài báo quốc tế(1): BQT00041
Tệp tin điện tử	https://www.nature.com/articles/s42003-025-09277-0
Tệp tin điện tử	https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg

MARC

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Tag	Giá trị
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001	33954
002	13
004	8571773E-02DC-4413-83D9-90C80D1EF1B6
005	202605131031
008	081223s2025 vm\| vie
009	1 0
039	[ ] \|y 20260513103143 \|z phuongntt
041	[ ] \|a Eng
084	[ ] \|a B2
100	[ ] \|a Phạm Thúy An
245	[ ] \|a IFN-γ and IL-17 elicit synergistic anti-mycobacterial responses by inhibiting coronin-1A retention
260	[ ] \|c 2025
260	[ ] \|b Nature
520	[ ] \|a This study demonstrates that the downregulation of coronin-1A retention on the phagosome is a synergistic pathway for IFN-γ and IL-17 that kills Mycobacterium tuberculosis (Mtb) in macrophages. IL-17 alone does not play a role in intracellular Mtb killing but potentiates the anti-mycobactericidal pathway of IFN-γ. Co-treatment of IFN-γ/IL-17 inhibited phosphorylation of STAT3, induced LRG47 expression, and reduced retention of coronin-1A on phagosome, thereby eliciting phagolysosomal fusion and bacterial killing, which was proved through response analysis of IFN-γ/IL-17 in Mtb-infected macrophages transfected with small interfering RNA of coro1a, lrg47, or stat1. Determination of adjunctive therapeutic effect of IFN-γ, IL-17, or both with anti-mycobacterial drugs showed that the bacterial load in the tissue of mice co-treated with IFN-γ/IL-17, even at 1 ng/mL concentration each, was more rapidly reduced compared to those of IFN-γ injection or chemotherapy alone. It inhibited the re-growth after treatment termination
650	[ ] \|a Public health
653	[ ] \|a Anti-mycobacterial
653	[ ] \|a Inhibiting coronin-1A retention
773	[ ] \|t Communications Biology
852	[ ] \|a 100 \|b Kho Bài báo quốc tế \|j (1): BQT00041
856	[ ] \|u https://www.nature.com/articles/s42003-025-09277-0
856	[1 ] \|u https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
890	[ ] \|a 1 \|b 0 \|c 0 \|d 0

Dòng	Mã vạch	Bản sao	Nơi lưu	Tình trạng	Cho phép yêu cầu
1	BQT00041	1	Kho Bài báo quốc tế
#1 BQT00041 Nơi lưu Kho Bài báo quốc tế Tình trạng

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