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Protective effect of metformin against dementia in patients with obesity Results from a global federated health network analysis

Protective effect of metformin against dementia in patients with obesity Results from a global federated health network analysis

 Wiley, 2025
 Eng
Mô tả biểu ghi
ID:34006
NLM C8
Tác giả CN Hoàng Đình Khánh
Nhan đề Protective effect of metformin against dementia in patients with obesity: Results from a global federated health network analysis
Thông tin xuất bản Wiley,2025
Tóm tắt The matched cohorts included 132 920 (BMI 25–29.9), 142 723 (30–34.9), 94 402 (35–39.9) and 82 732 (over 40) patients per group. After 10 years of follow-up, metformin users exhibited significantly lower risks of both dementia and all-cause mortality compared to controls. Specifically, the hazard ratios for dementia across each BMI group were 0.875 (95% confidence interval [CI]: 0.848–0.904), 0.917 (0.885–0.951), 0.878 (0.834–0.924) and 0.891 (0.834–0.953), respectively. For all-cause mortality, the corresponding hazard ratios were 0.719 (0.701–0.737), 0.727 (0.708–0.746), 0.717 (0.694–0.741) and 0.743 (0.717–0.771).
Thuật ngữ chủ đề Metabolism
Từ khóa tự do Obesity; Metformin against dementia
Địa chỉ 100Kho Bài báo quốc tế(1): BQT00083
Tệp tin điện tử https://doi.org/10.1111/dom.16647
Tệp tin điện tử https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
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100[ ] |a Hoàng Đình Khánh
245[ ] |a Protective effect of metformin against dementia in patients with obesity: Results from a global federated health network analysis
260[ ] |b Wiley, |c 2025
520[ ] |a The matched cohorts included 132 920 (BMI 25–29.9), 142 723 (30–34.9), 94 402 (35–39.9) and 82 732 (over 40) patients per group. After 10 years of follow-up, metformin users exhibited significantly lower risks of both dementia and all-cause mortality compared to controls. Specifically, the hazard ratios for dementia across each BMI group were 0.875 (95% confidence interval [CI]: 0.848–0.904), 0.917 (0.885–0.951), 0.878 (0.834–0.924) and 0.891 (0.834–0.953), respectively. For all-cause mortality, the corresponding hazard ratios were 0.719 (0.701–0.737), 0.727 (0.708–0.746), 0.717 (0.694–0.741) and 0.743 (0.717–0.771).
650[ ] |a Metabolism
653[ ] |a Obesity
653[ ] |a Metformin against dementia
691[ ] |a CTĐT Thạc sĩ Nội khoa
691[ ] |a CTĐT Tiến sĩ Nội khoa
773[ ] |t Diabetes, Obesity and Metabolism
852[ ] |a 100 |b Kho Bài báo quốc tế |j (1): BQT00083
856[ ] |u https://doi.org/10.1111/dom.16647
856[1 ] |u https://lib.hpmu.edu.vn/kiposdata2/tapchi2026/anhbiatc/biabbqt_thumbimage.jpg
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1 BQT00083 1 Kho Bài báo quốc tế
#1 BQT00083
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